Symbol
Name
ID

Picalm
phosphatidylinositol binding clathrin assembly protein
MGI:2385902

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Acute myeloid leukemia
Disease(s) Associated with PICALM	Acute myeloid leukemia
acute myeloid leukemia

Mouse Phenotypes

enlarged spleen

abnormal erythropoiesis

abnormal B cell differentiation

anemia

hypochromic microcytic anemia

microcytic anemia

impaired hematopoiesis

abnormal bone marrow cell morphology/development

decreased bone marrow cell number

decreased erythroid progenitor cell number

decreased erythroblast number

increased erythroblast number

abnormal erythrocyte morphology

decreased erythrocyte cell number

decreased hematocrit

decreased hemoglobin content

decreased mean corpuscular hemoglobin

decreased mean corpuscular volume

increased red blood cell distribution width

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

reticulocytosis

abnormal fetal liver hematopoietic progenitor cell morphology

decreased spleen B cell follicle number

abnormal erythrocyte physiology

Availability

Mouse Genotype

Picalm^fit1-494SB/Picalm^fit1-494SB

Picalm^fit1-764SB/Picalm^fit1-764SB

Picalm^fit1-3452SB/Picalm^fit1-3452SB

Picalm^fit1-4226SB/Picalm^fit1-4226SB

Picalm^fit1-4397SB/Picalm^fit1-4397SB

Picalm^tm1.2Tmae/Picalm^tm1.2Tmae

Picalm^tm1Towa/Picalm^tm1Towa

Picalm^tm1.2Tmae/Picalm⁺

Picalm^tm1.1Tmae/Picalm^tm1.1Tmae
Tg(Mx1-cre)1Cgn/0 (conditional)

Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/0
Picalm^tm1.1Tmae/Picalm^tm1.1Tmae (conditional)

Picalm^tm1.1Tmae/Picalm^tm1.1Tmae
Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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